Question

Match List I with List II and choose the correct answer.

• A. A-III, B-II, C-IV, D-I
• B. A-IV, B-III, C-II, D-I
• C. A-II, B-III, C-IV, D-I
• D. A-III, B-IV, C-I, D-II

Hint:

• $\beta$-lactams (like ampicillin) → Cell wall synthesis inhibition
• Aminoglycosides (like kanamycin) → 30S subunit
• Chloramphenicol → 50S subunit
• Translocation blockers → Hygromycin-B

Answer 1

The Correct Option is A

Concept: Different antibiotics act by targeting specific bacterial processes such as protein synthesis or cell wall formation.
• Some antibiotics inhibit ribosomal subunits (30S or 50S).
• Others interfere with cell wall synthesis or ribosomal translocation.

Step 1: Matching each antibiotic with its mechanism.

• Ampicillin: A $\beta$-lactam antibiotic that inhibits cell wall synthesis → III
• Kanamycin: An aminoglycoside that binds to 30S ribosomal subunit → II
• Hygromycin-B: Inhibits protein synthesis by interfering with ribosomal translocation → IV
• Chloramphenicol: Binds to 50S ribosomal subunit and inhibits translation → I

Step 2: Writing the correct combination.
\[ A \rightarrow III,\quad B \rightarrow II,\quad C \rightarrow IV,\quad D \rightarrow I \] Thus, the correct option is (A).