Question

logP is a measure of drug-likeliness in Lipinsky’s Rule of Five. P denotes

• A. Partition coefficient
• B. Polymer concentration
• C. Plasma coefficient
• D. Pyrogen concentration

Hint:

• logP → Lipophilicity measure
• Higher logP → More lipid soluble

Answer 1

The Correct Option is A

Concept: In Lipinski’s Rule of Five, logP represents the logarithm of the partition coefficient (P), which measures the distribution of a compound between two immiscible phases (usually octanol and water).
• Indicates lipophilicity of a drug
• Important for absorption and permeability

Step 1: Understanding logP.
\[ P = \frac{\text{Concentration in octanol phase}}{\text{Concentration in aqueous phase}} \] logP = logarithm of this partition coefficient.

Step 2: Analyzing options.

• Partition coefficient: Correct definition of P.
• Polymer concentration: Incorrect.
• Plasma coefficient: Incorrect.
• Pyrogen concentration: Incorrect.

Step 3: Selecting the correct answer.
Thus, P denotes partition coefficient.