Question

In \(\beta\)-Oxidation, \(\beta\)-Ketoacyl-CoA dehydrogenase catalyzes which of the following reactions?

• A. Palmitoyl CoA \(\longrightarrow\) trans \(\Delta\)2 Enoyl CoA
• B. trans \(\Delta\)2 Enoyl CoA \(\longrightarrow\) \(\beta\)-Hydroxy acyl CoA
• C. \(\beta\)-Hydroxy acyl CoA \(\longrightarrow\) \(\beta\)-Keto acyl CoA
• D. \(\beta\)-Keto acyl CoA \(\longrightarrow\) Acyl CoA

Hint:

\(\beta\)-Oxidation steps:
Dehydrogenation \(\rightarrow\) Hydration \(\rightarrow\) Oxidation \(\rightarrow\) Thiolysis.
Each step uses different enzymes.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
\(\beta\)-Oxidation has four steps.
Each step is catalyzed by a specific enzyme.

Step 2: Key Formula or Approach:
No specific formula.
Need to know the steps of \(\beta\)-oxidation.

Step 3: Detailed Explanation:
The steps of \(\beta\)-oxidation are:
1. Dehydrogenation: Acyl CoA \(\rightarrow\) trans \(\Delta\)2 Enoyl CoA (Acyl CoA dehydrogenase).
2. Hydration: trans \(\Delta\)2 Enoyl CoA \(\rightarrow\) \(\beta\)-Hydroxy acyl CoA (Enoyl CoA hydratase).
3. Oxidation: \(\beta\)-Hydroxy acyl CoA \(\rightarrow\) \(\beta\)-Keto acyl CoA (\(\beta\)-Hydroxy acyl CoA dehydrogenase).
4. Thiolysis: \(\beta\)-Keto acyl CoA \(\rightarrow\) Acyl CoA + Acetyl CoA (Thiolase).
Thus, \(\beta\)-Ketoacyl-CoA dehydrogenase catalyzes step 3.

Step 4: Final Answer:
\(\beta\)-Ketoacyl-CoA dehydrogenase catalyzes \(\beta\)-Hydroxy acyl CoA \(\longrightarrow\) \(\beta\)-Keto acyl CoA.
Hence, the correct option is (C).