Question

If a globular protein is present in a nonpolar solvent then the surface of the protein contain amino acids with:
A. Polar side chain
B. Nonpolar side chain
C. Polar but uncharged side chain
Choose the correct answer from the options given below:

• A. A, B and C only
• B. A and B only
• C. B and C only
• D. A and C only

Hint:

In nonpolar solvent: hydrophobic amino acids on surface.
In aqueous solvent: hydrophilic amino acids on surface.
Protein folding is driven by hydrophobic effect.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Protein folding is influenced by the solvent environment.
Amino acids with different side chains behave differently in nonpolar solvents.

Step 2: Key Formula or Approach:
No specific formula.
Need to understand protein folding in different solvents.

Step 3: Detailed Explanation:
In a nonpolar solvent, the protein surface would contain:
- Nonpolar (hydrophobic) side chains (B) - these interact favorably with the solvent.
- Polar but uncharged side chains (C) - these may also be present.
Polar charged side chains (A) would not be on the surface.
Thus, B and C are correct.

Step 4: Final Answer:
The surface of the protein would contain nonpolar and polar uncharged side chains.
Hence, the correct option is (C).