Question:
Gluconeogenesis from lactate needs all of the following except?
Gluconeogenesis from lactate needs all of the following except?
Show Hint
Cori cycle uses lactate to pyruvate to glucose; pyruvate to alanine is the glucose-alanine cycle.
Updated On: Jun 24, 2026
- Transport of lactate from muscle to liver
- Conversion of lactate to pyruvate
- Transamination of pyruvate to alanine
- None of the above
Show Solution
Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: This is a negative (except) question. Identify the step that is NOT part of converting lactate into glucose.
Step 2: The Cori cycle. Lactate made by exercising or anaerobic muscle is released into blood and carried to the liver. So transport of lactate from muscle to liver (option a) is required.
Step 3: In the liver, lactate dehydrogenase converts lactate back to pyruvate. So conversion of lactate to pyruvate (option b) is required. Pyruvate then enters gluconeogenesis to form glucose.
Step 4: Transamination of pyruvate to alanine (option c) belongs to the glucose-alanine cycle, NOT to gluconeogenesis from lactate. Converting pyruvate to alanine would divert pyruvate away from glucose synthesis, so this step is not needed. Hence option c is the correct except answer.
Step 2: The Cori cycle. Lactate made by exercising or anaerobic muscle is released into blood and carried to the liver. So transport of lactate from muscle to liver (option a) is required.
Step 3: In the liver, lactate dehydrogenase converts lactate back to pyruvate. So conversion of lactate to pyruvate (option b) is required. Pyruvate then enters gluconeogenesis to form glucose.
Step 4: Transamination of pyruvate to alanine (option c) belongs to the glucose-alanine cycle, NOT to gluconeogenesis from lactate. Converting pyruvate to alanine would divert pyruvate away from glucose synthesis, so this step is not needed. Hence option c is the correct except answer.
Was this answer helpful?
0
0
Top NEET PG Biochemistry Questions
- Which of the following clotting factors is needed for gamma-glutamyl carboxylase?
- A patient presented with diarrhea, dermatitis, and dementia. Which of the following vitamin deficiencies would you suspect in this patient?
- A young boy presents to the OPD with hypoglycemia and muscle cramps, on exertion or while playing. Then he becomes normal after resting for a while. These episodes are recurrent after a period of activity. He has decreased serum lactate and glucose levels. Which of the following diseases is he most likely to be suffering from?
- A family consumes only polished rice. Which of the following combinations of vitamin deficiency and enzymatic defect will be present in this family?
- A chronic alcoholic patient presented to the casualty with confusion, ataxia, and painful eye movements. What could be the vitamin deficiency seen in this patient?
View More Questions
Top NEET PG Gluconeogenesis Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions