Question:
Button ulcers in colon of pigs are seen in
(A). Classical swine fever
(B). Toxoplasmosis
(C). Intestinal salmonellosis
(D). Glasser's disease
Choose the correct answer from the options given below:
Button ulcers in colon of pigs are seen in
(A). Classical swine fever
(B). Toxoplasmosis
(C). Intestinal salmonellosis
(D). Glasser's disease
Choose the correct answer from the options given below:
(A). Classical swine fever
(B). Toxoplasmosis
(C). Intestinal salmonellosis
(D). Glasser's disease
Choose the correct answer from the options given below:
Show Hint
In swine pathology, "button ulcers" in the large intestine are highly diagnostic.
The top two differentials for button ulcers are Classical Swine Fever (pestivirus) and Salmonellosis (bacterial).
The top two differentials for button ulcers are Classical Swine Fever (pestivirus) and Salmonellosis (bacterial).
Updated On: Jul 14, 2026
- (A), (B) and (C) only.
- (A) and (C) only.
- (B), (C) and (D) only.
- (A) and (D) only.
Show Solution
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The Correct Option is B
Solution and Explanation
Step 1: Understanding the Concept:
Button ulcers are characteristic concentric, raised necrotic lesions found in the mucosa of the cecum and colon of pigs.
These lesions are caused by localized thrombosis and necrosis of the intestinal mucosa resulting from infectious vasculitis.
Detailed Explanation:
Let us analyze the involvement of each pathogen in the formation of button ulcers:
(A) Classical Swine Fever (CSF): The CSF virus has a strong tropism for vascular endothelial cells, causing systemic vasculitis and endothelial damage.
In the large intestine, this damage leads to infarction of the submucosal blood vessels.
The overlying mucosa undergoes ischemic necrosis, forming focal circular necrotic lesions.
As these areas are encrusted with fibrin, cellular debris, and feces, they form raised, concentric "button ulcers."
Thus, CSF is a classic cause of button ulcers.
(C) Intestinal Salmonellosis: Infections caused by Salmonella enterica serovar Typhimurium or Choleraesuis also cause necrotizing enterocolitis.
The vascular thrombosis caused by salmonella endotoxins produces focal ischemic necrosis in the colon.
These lesions develop into circular, raised, fibrinonecrotic ulcers that resemble the button ulcers of CSF.
Thus, salmonellosis is also associated with button ulcers.
(B) Toxoplasmosis does not typically produce localized mucosal button ulcers in the colon of pigs.
(D) Glasser's disease is caused by Glaesserella parasuis and is characterized by fibrinous polyserositis, meningitis, and arthritis, not colonic ulcers.
Step 2: Final Answer:
Since button ulcers are classically seen in Classical Swine Fever and Intestinal Salmonellosis, the correct option is (B).
Button ulcers are characteristic concentric, raised necrotic lesions found in the mucosa of the cecum and colon of pigs.
These lesions are caused by localized thrombosis and necrosis of the intestinal mucosa resulting from infectious vasculitis.
Detailed Explanation:
Let us analyze the involvement of each pathogen in the formation of button ulcers:
(A) Classical Swine Fever (CSF): The CSF virus has a strong tropism for vascular endothelial cells, causing systemic vasculitis and endothelial damage.
In the large intestine, this damage leads to infarction of the submucosal blood vessels.
The overlying mucosa undergoes ischemic necrosis, forming focal circular necrotic lesions.
As these areas are encrusted with fibrin, cellular debris, and feces, they form raised, concentric "button ulcers."
Thus, CSF is a classic cause of button ulcers.
(C) Intestinal Salmonellosis: Infections caused by Salmonella enterica serovar Typhimurium or Choleraesuis also cause necrotizing enterocolitis.
The vascular thrombosis caused by salmonella endotoxins produces focal ischemic necrosis in the colon.
These lesions develop into circular, raised, fibrinonecrotic ulcers that resemble the button ulcers of CSF.
Thus, salmonellosis is also associated with button ulcers.
(B) Toxoplasmosis does not typically produce localized mucosal button ulcers in the colon of pigs.
(D) Glasser's disease is caused by Glaesserella parasuis and is characterized by fibrinous polyserositis, meningitis, and arthritis, not colonic ulcers.
Step 2: Final Answer:
Since button ulcers are classically seen in Classical Swine Fever and Intestinal Salmonellosis, the correct option is (B).
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