Step 1: Concept
Insulin therapy.
Step 2: Meaning
Why insulin requires injection and the historical issues with animal insulin.
Step 3: Analysis
Insulin is a protein, so it is digested if taken orally (A is true). Animal insulin can cause immunogenic reactions in humans (R is true). However, animal insulin's antigenicity is not the reason it cannot be taken orally; digestive enzymes are.
Step 4: Conclusion
Both are true, but R does not explain A.
Final Answer: (B)