Step 1: Define anti-cancer drugs.
- Anti-cancer drugs, or chemotherapeutic agents, inhibit cell division or induce cell death in rapidly dividing cells.
Step 2: Check each option.
- Hetrozen: Not a recognized anticancer drug, may be an antimicrobial.
- Aureomycin: Antibiotic (tetracycline), not used for cancer treatment.
- Methotrexate: Folic acid analog; inhibits dihydrofolate reductase, blocking DNA synthesis in cancer cells - Correct
- Isonicotinic acid hydrazide (INH): Anti-tuberculosis drug, not anticancer.
Step 3: Mechanism of Methotrexate.
- Inhibits DNA replication in rapidly dividing cells.
- Used in leukemia, lymphoma, and some solid tumors.
Step 4: Pharmacological significance.
- Selectively targets cells with high mitotic rate.
- Can cause side effects in normal rapidly dividing cells (bone marrow, gut).
Step 5: Conclusion.
- Methotrexate is the correct anticancer drug among the options.