Question

All of the following are TNFα inhibitor EXCEPT

• A. Etanercept
• B. Infliximab
• C. Adalimumab
• D. Basiliximab

Answer 1

The Correct Option is D

To solve this question, we need to identify which of the options listed is not a TNFα (Tumor Necrosis Factor alpha) inhibitor.

TNFα inhibitors are a class of medications used primarily to treat inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis by blocking the action of TNFα, a substance in the body that causes inflammation.

Let us analyze each of the options provided:

1. Etanercept: Etanercept is a biologic medication that acts as a decoy receptor for TNF, thereby inhibiting its inflammatory activity. Thus, it is a TNFα inhibitor.
2. Infliximab: Infliximab is a monoclonal antibody that binds with high affinity to the soluble and transmembrane forms of TNFα, inhibiting its inflammatory effects. Therefore, Infliximab is also a TNFα inhibitor.
3. Adalimumab: Adalimumab is a fully human monoclonal antibody that binds to TNFα, preventing it from activating TNF receptors and exerting its pro-inflammatory effects. It is a TNFα inhibitor.
4. Basiliximab: Unlike the other options, Basiliximab is not a TNFα inhibitor. It is a monoclonal antibody that blocks the interleukin-2 (IL-2) receptor alpha chain (CD25 antigen) on activated T-lymphocytes, and is primarily used in transplantation to prevent organ rejection. Therefore, Basiliximab is the correct answer.

Thus, the option that is not a TNFα inhibitor is Basiliximab.