A reaction mixture containing optimum condition of reaction for enzymes, E1, E2 and E3 react with a particular substrate S. Km of E1, E2 and E3 for that particular substrate S are $5\times10^{-12}$, $5\times10^{-10}$ and $5\times10^{-15}$ respectively then
(A) E1 is more specific for that substrate than E2
(B) E2 is more specific for that substrate than E3
(C) E3 is more specific for that substrate than E1
(D) E3 is more specific for that substrate than E2
Choose the correct answer from the options given below: