Question:
Which one of the followings is a reason for development of myelophthisic anemia?
Which one of the followings is a reason for development of myelophthisic anemia?
Show Hint
Remember:
- Myelophthisis = "Marrow crowding" or physical replacement of bone marrow.
- It is most commonly caused by metastatic tumors, leukemia, lymphosarcoma, or myelofibrosis.
- Myelophthisis = "Marrow crowding" or physical replacement of bone marrow.
- It is most commonly caused by metastatic tumors, leukemia, lymphosarcoma, or myelofibrosis.
Updated On: Jul 23, 2026
- Radiation injury
- Equine infectious anemia
- Lymphosarcoma
- Deficiency of copper and cobalt
Show Solution
Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: Understanding the Concept:
Myelophthisic anemia is a severe, non-regenerative form of anemia.
It occurs when the normal, hematopoietic tissue of the bone marrow is physically replaced, crowded out, or destroyed by abnormal, non-hematopoietic tissue or cells.
Step 2: Detailed Explanation:
Let us analyze each of the listed conditions:
- Radiation injury (A): Exposure to ionizing radiation directly damages the DNA of rapidly dividing hematopoietic stem cells, leading to bone marrow hypoplasia or aplasia (aplastic anemia). It does not involve physical tissue replacement (myelophthisis).
- Equine infectious anemia (B): EIA is a lentiviral disease of equids characterized by immune-mediated hemolysis and erythrophagocytosis. It is a hemolytic (destructive) anemia, not a space-occupying marrow disorder.
- Lymphosarcoma (C): Lymphosarcoma (malignant lymphoma) is a common systemic neoplastic disease of lymphoid tissues.
In advanced stages, neoplastic lymphocytes can extensively infiltrate and colonize the bone marrow cavity.
This neoplastic infiltration physically crowds out and replaces the normal erythroid, myeloid, and megakaryocytic stem cells.
This physical replacement of normal marrow by tumor cells is the definition of myelophthisis, which results in myelophthisic anemia.
- Deficiency of copper and cobalt (D): Copper deficiency interferes with iron transport and utilization, and cobalt deficiency (in ruminants) blocks Vitamin B12 synthesis.
These lead to microcytic/normocytic nutritional anemias due to metabolic blocks, not space-occupying bone marrow lesions.
Therefore, Lymphosarcoma is the correct cause of myelophthisic anemia.
Step 3: Final Answer:
The correct option is (C).
Myelophthisic anemia is a severe, non-regenerative form of anemia.
It occurs when the normal, hematopoietic tissue of the bone marrow is physically replaced, crowded out, or destroyed by abnormal, non-hematopoietic tissue or cells.
Step 2: Detailed Explanation:
Let us analyze each of the listed conditions:
- Radiation injury (A): Exposure to ionizing radiation directly damages the DNA of rapidly dividing hematopoietic stem cells, leading to bone marrow hypoplasia or aplasia (aplastic anemia). It does not involve physical tissue replacement (myelophthisis).
- Equine infectious anemia (B): EIA is a lentiviral disease of equids characterized by immune-mediated hemolysis and erythrophagocytosis. It is a hemolytic (destructive) anemia, not a space-occupying marrow disorder.
- Lymphosarcoma (C): Lymphosarcoma (malignant lymphoma) is a common systemic neoplastic disease of lymphoid tissues.
In advanced stages, neoplastic lymphocytes can extensively infiltrate and colonize the bone marrow cavity.
This neoplastic infiltration physically crowds out and replaces the normal erythroid, myeloid, and megakaryocytic stem cells.
This physical replacement of normal marrow by tumor cells is the definition of myelophthisis, which results in myelophthisic anemia.
- Deficiency of copper and cobalt (D): Copper deficiency interferes with iron transport and utilization, and cobalt deficiency (in ruminants) blocks Vitamin B12 synthesis.
These lead to microcytic/normocytic nutritional anemias due to metabolic blocks, not space-occupying bone marrow lesions.
Therefore, Lymphosarcoma is the correct cause of myelophthisic anemia.
Step 3: Final Answer:
The correct option is (C).
Was this answer helpful?
0
0
Top ICAR AIEEA Veterinary Science Questions
- In ox vallate papillae are
- Spiral colon is characteristic of
- Assertion (A) : Stratum lucidum is translucent layer present between stratum spinosum and stratum granulosum
Reasoning (R) : Stratum lucidum is translucent due to presence of eledin protein.
In light of the above statements, choose the correct answer from the options given below. - Statement (I): Keratinocytes contain melanin pigment in the form of melanosomes.
Statement (II): Melanin pigment is produced by keratinocytes with the help of Tyrosinase enzyme.
In light of the above statements, choose the most appropriate answer from the options given below. - Which of the following is true for mast cells?
(A). These cells are common in loose connective tissue.
(B). These cells take metachromatic stain.
(C). These cells are rich in histamine, heparin and proteases.
(D). These cells contain basophilic cytoplasmic granules.
Choose the correct answer from the options given below:
View More Questions
Top ICAR AIEEA Veterinary Medicine Questions
- Normal serum calcium level in cattle is
- On echocardiography, dilated cardiomyopathy in dogs is characterized best by which of the following findings?
(A). Decreased ejection fraction
(B). Decreased fraction shortening
(C). Increased mitral valve E-point to septal separation (EPSS)
(D). Decreased LA/AO ratio
Choose the correct answer from the options given below: - Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R).
Assertion (A): Potassium may be supplemented by IV route at a rate over 0.5mEq/kg/hour in animals.
Reason (R): Adverse cardiac effects can occur above 0.5mEq/kg/hour rate.
In light of the above statements, choose the correct answer from the options given below. - Given below are two statements:
Statement (I): Myxedema on the forehead and face, resulting in a puffy appearance and thickened skin folds above the eyes is most common in hypothyroidism.
Statement (II): Above-described signs are also important clinical signs in case diabetes mellites.
In light of the above statements, choose the most appropriate answer from the options given below. - 'Cud dropping' condition may be observed in cattle due to
View More Questions
Top ICAR AIEEA Questions
- Which of the following statements is false?
- Which of the following is an example of an inventory?
- According to Adam Smith, productivity gains could be brought about through .
- The supply curve for an artificially scarce good is .
- Which of the following would not be considered an opportunity cost of paid employment?
View More Questions