Which one of the following statements is NOT true about the role of primase enzyme in DNA replication?
Show Hint
- It does not need a primer to function.
- It is a specialized polymerase that requires dNTPs.
- It is an RNA polymerase using ribonucleoside triphosphates.
- It synthesizes primer for both leading and lagging strands.
The Correct Option is B
Solution and Explanation
Step 1: Concept
DNA polymerases cannot initiate a new DNA strand; they require a $3'-OH$ group provided by a primer.
Step 2: Analysis of Primase
Primase is a DNA-dependent RNA polymerase. It synthesizes short RNA primers using ribonucleotides (NTPs: ATP, UTP, GTP, CTP), not deoxyribonucleotides (dNTPs).
Step 3: Reasoning
Statement (A) is true (it starts de novo). (C) is true (it makes RNA). (D) is true (both strands need a starting point).
Step 4: Conclusion
Statement (B) is false because primase uses NTPs, not dNTPs. Final Answer: (B)
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