Question

Francis & Crick proposed the scheme called Central Dogma in 1958. Which of the following processes was NOT covered in this scheme?

• A. Replication
• B. Transcription
• C. Reverse transcription
• D. Translation

Hint:

The Central Dogma initially described a one-way flow from DNA → RNA → Protein. Reverse transcription (RNA → DNA) was discovered later and is an exception to the original scheme.

Answer 1

The Correct Option is C

Step 1: Understand the Central Dogma. 
The Central Dogma of molecular biology, proposed by Francis Crick in 1958, describes the unidirectional flow of genetic information: \[ {DNA} \xrightarrow{{transcription}} {RNA} \xrightarrow{{translation}} {Protein} \] Step 2: Processes originally included.
The processes covered were:
Replication: DNA makes copies of itself.
Transcription: DNA to RNA.
Translation: RNA to protein.
Step 3: Reverse transcription not included. 
Reverse transcription (RNA to DNA) was not part of the original Central Dogma and was only discovered later with the study of retroviruses (e.g., HIV). 
Conclusion: Reverse transcription was not included in the original Central Dogma.