Question:
Which one of the following nutrient has a role in clotting of blood?
Which one of the following nutrient has a role in clotting of blood?
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Vitamin K antagonists like Warfarin block the recycling of Vitamin K, inhibiting the activation of factors II, VII, IX, and X, and are used clinically as anticoagulants.
Updated On: Aug 5, 2026
- Iron
- Folic acid
- Vitamin \(\text{B}_{12}\)
- Vitamin K
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The Correct Option is D
Solution and Explanation
Step 1: Understanding the Concept:
Blood coagulation is a highly regulated cascade of enzymatic reactions that prevents blood loss following vascular injury.
Several proteins in this cascade require post-translational modification to become biologically active.
Step 2: Detailed Explanation:
Vitamin K (phylloquinone/menaquinone) is an essential cofactor for the enzyme gamma-glutamyl carboxylase.
This enzyme catalyzes the carboxylation of glutamic acid residues on key clotting factors synthesized by the liver, including:
- Prothrombin (Factor II)
- Factor VII
- Factor IX
- Factor X
The carboxylation of these proteins allows them to bind calcium ions (\(\text{Ca}^{2+}\)) and attach to platelet membrane phospholipids, which is necessary for their activation.
In the absence of Vitamin K, these clotting factors are synthesized in an inactive, non-carboxylated form, leading to impaired clotting and a high risk of hemorrhaging.
Let us identify the functions of the other options:
- Iron is essential for hemoglobin synthesis and oxygen transport.
- Folic acid and Vitamin \(\text{B}_{12}\) are cofactors in DNA synthesis and red blood cell maturation.
Step 3: Final Answer:
Vitamin K is the nutrient required for blood clotting.
Blood coagulation is a highly regulated cascade of enzymatic reactions that prevents blood loss following vascular injury.
Several proteins in this cascade require post-translational modification to become biologically active.
Step 2: Detailed Explanation:
Vitamin K (phylloquinone/menaquinone) is an essential cofactor for the enzyme gamma-glutamyl carboxylase.
This enzyme catalyzes the carboxylation of glutamic acid residues on key clotting factors synthesized by the liver, including:
- Prothrombin (Factor II)
- Factor VII
- Factor IX
- Factor X
The carboxylation of these proteins allows them to bind calcium ions (\(\text{Ca}^{2+}\)) and attach to platelet membrane phospholipids, which is necessary for their activation.
In the absence of Vitamin K, these clotting factors are synthesized in an inactive, non-carboxylated form, leading to impaired clotting and a high risk of hemorrhaging.
Let us identify the functions of the other options:
- Iron is essential for hemoglobin synthesis and oxygen transport.
- Folic acid and Vitamin \(\text{B}_{12}\) are cofactors in DNA synthesis and red blood cell maturation.
Step 3: Final Answer:
Vitamin K is the nutrient required for blood clotting.
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