Question

Which one of the following NSAIDs is a selective COX-2 inhibitor?

• A. Celecoxib
• B. Ibuprofen
• C. Indomethacin
• D. Piroxicam

Hint:

Suffix "-coxib" = Selective COX-2 inhibitor.

Answer 1

The Correct Option is A

Step 1: Concept
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) work by inhibiting cyclooxygenase (COX) enzymes.

Step 2: Meaning
Selective COX-2 inhibitors specifically target the inducible COX-2 enzyme responsible for inflammation, sparing the constitutive COX-1 found in the stomach.

Step 3: Analysis
Ibuprofen, Indomethacin, and Piroxicam are traditional, non-selective NSAIDs that inhibit both COX-1 and COX-2. Celecoxib belongs to the "coxib" class of selective inhibitors.

Step 4: Conclusion
Celecoxib is the selective COX-2 inhibitor among the choices.

Final Answer: (A)