Question:
Which one among the following drugs has the IUPAC \(α.α.\overline{α}.\overline{α}\)-tetramethyl 5-(1 H-1, 2,4-triazole- 1-ylmethyl)-1,3-benzenediacetonitrile:
Which one among the following drugs has the IUPAC \(α.α.\overline{α}.\overline{α}\)-tetramethyl 5-(1 H-1, 2,4-triazole- 1-ylmethyl)-1,3-benzenediacetonitrile:
Updated On: Feb 24, 2026
- Letrozole
- Aminglutethimide
- Exemestane
- Anastrozole
Show Solution
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The Correct Option is D
Solution and Explanation
The question asks us to identify the drug given by the IUPAC name \(α.α.\overline{α}.\overline{α}\)-tetramethyl 5-(1H-1,2,4-triazole-1-ylmethyl)-1,3-benzenediacetonitrile. Let's break down the options and find the correct one.
- Letrozole: The IUPAC name of Letrozole is 4,4'-(1H-1,2,4-triazole-1-ylmethanediyl)dibenzonitrile. This does not match the given IUPAC name.
- Aminglutethimide: Its structure and IUPAC name are completely different from the given name, as it contains an imide structure, not a benzenediacetonitrile.
- Exemestane: The IUPAC name for Exemestane is 6-methylenandrosta-1,4-diene-3,17-dione. This is not a match and is a different class of compounds (steroidal aromatase inhibitors).
- Anastrozole: The IUPAC for Anastrozole is 2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropanenitrile). This matches the given IUPAC name, which specifies a tetramethyl group and a triazole ring linked via a methyl group to a phenylene structure with nitrile groups. Thus, Anastrozole is the correct answer.
Conclusion: After analyzing the chemical structure and IUPAC names of the options provided, Anastrozole is the correct answer as it matches the unique structural IUPAC identifiers given in the question.
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