Question

Which one among the following drugs has the IUPAC \(α.α.\overline{α}.\overline{α}\)-tetramethyl 5-(1 H-1, 2,4-triazole- 1-ylmethyl)-1,3-benzenediacetonitrile:

• A. Letrozole
• B. Aminglutethimide
• C. Exemestane
• D. Anastrozole

Answer 1

The Correct Option is D

The question asks us to identify the drug given by the IUPAC name \(α.α.\overline{α}.\overline{α}\)-tetramethyl 5-(1H-1,2,4-triazole-1-ylmethyl)-1,3-benzenediacetonitrile. Let's break down the options and find the correct one.

1. Letrozole: The IUPAC name of Letrozole is 4,4'-(1H-1,2,4-triazole-1-ylmethanediyl)dibenzonitrile. This does not match the given IUPAC name.
2. Aminglutethimide: Its structure and IUPAC name are completely different from the given name, as it contains an imide structure, not a benzenediacetonitrile.
3. Exemestane: The IUPAC name for Exemestane is 6-methylenandrosta-1,4-diene-3,17-dione. This is not a match and is a different class of compounds (steroidal aromatase inhibitors).
4. Anastrozole: The IUPAC for Anastrozole is 2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropanenitrile). This matches the given IUPAC name, which specifies a tetramethyl group and a triazole ring linked via a methyl group to a phenylene structure with nitrile groups. Thus, Anastrozole is the correct answer.

Conclusion: After analyzing the chemical structure and IUPAC names of the options provided, Anastrozole is the correct answer as it matches the unique structural IUPAC identifiers given in the question.