Question

Given below are the two statements
Statement I: Glucose‐6‐phosphate can be formed from glucose, but not from glycogen.
Statement II: Glucose‐1‐phosphate may be hydrolyzed to yield free glucose in liver.
Choose the most appropriate answer from the options given below:

• A. Both Statement I and Statement II are correct
• B. Both Statement I and Statement II are incorrect
• C. Statement I is correct but Statement II is incorrect
• D. Statement I is incorrect but Statement II is correct

Answer 1

The Correct Option is B

Let us analyze the two statements provided to determine which is correct and which is not.

Statement I: Glucose‐6‐phosphate can be formed from glucose, but not from glycogen.

This statement is incorrect because glucose-6-phosphate can indeed be formed from glycogen. During glycogenolysis, glycogen is broken down into glucose-1-phosphate, which is then converted into glucose-6-phosphate by the enzyme phosphoglucomutase. Thus, glucose-6-phosphate can be formed from both glucose and glycogen.

Statement II: Glucose‐1‐phosphate may be hydrolyzed to yield free glucose in liver.

This statement is also incorrect. In the liver, glucose-1-phosphate is not directly hydrolyzed to produce free glucose. Instead, glucose-1-phosphate is converted to glucose-6-phosphate by phosphoglucomutase. Then, glucose-6-phosphate can be converted to free glucose through the action of the enzyme glucose-6-phosphatase, which is present in the liver.

Conclusion

Both Statement I and Statement II are incorrect based on biochemical pathways involved in glycogenolysis and glucose metabolism. Therefore, the correct answer is:

• Both Statement I and Statement II are incorrect.