Question:
Which of these is the best indicator of alcoholic cirrhosis?
Which of these is the best indicator of alcoholic cirrhosis?
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An isolated, disproportionate elevation of GGT is a classic diagnostic hallmark of alcohol abuse and alcohol-related liver injury.
Updated On: Jul 6, 2026
- GGT
- ALT
- AST
- Alkaline phosphatase
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Concept:
Serum enzyme levels are vital biomarkers in diagnostic pathology to identify liver damage and differentiate between its etiological causes.
Step 2: Detailed Explanation:
- Gamma-Glutamyl Transferase, GGT (A): GGT is an enzyme found in high concentrations in hepatocytes. Its synthesis is specifically induced by alcohol ingestion. Even in the absence of advanced liver disease, heavy drinking significantly increases serum GGT levels. In cases of alcoholic cirrhosis, GGT is markedly elevated, making it the most sensitive and specific diagnostic indicator.
- ALT (B) and AST (C): These transaminases are general markers of hepatocellular injury but are less specific to alcohol-induced damage.
- Alkaline Phosphatase (D): Primarily a marker for cholestasis and bone disorders.
Step 3: Final Answer:
The best indicator of alcoholic cirrhosis is GGT, corresponding to option (A).
Serum enzyme levels are vital biomarkers in diagnostic pathology to identify liver damage and differentiate between its etiological causes.
Step 2: Detailed Explanation:
- Gamma-Glutamyl Transferase, GGT (A): GGT is an enzyme found in high concentrations in hepatocytes. Its synthesis is specifically induced by alcohol ingestion. Even in the absence of advanced liver disease, heavy drinking significantly increases serum GGT levels. In cases of alcoholic cirrhosis, GGT is markedly elevated, making it the most sensitive and specific diagnostic indicator.
- ALT (B) and AST (C): These transaminases are general markers of hepatocellular injury but are less specific to alcohol-induced damage.
- Alkaline Phosphatase (D): Primarily a marker for cholestasis and bone disorders.
Step 3: Final Answer:
The best indicator of alcoholic cirrhosis is GGT, corresponding to option (A).
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