Question:
Which of these function as xanthine oxidase inhibitor?
Which of these function as xanthine oxidase inhibitor?
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Allopurinol is the classic drug used to treat gout. It reduces uric acid production by directly inhibiting the rate-limiting enzyme xanthine oxidase.
Updated On: Jul 6, 2026
- Cyclo-oxygenase
- Lipo-oxygenase
- Allopurinol
- Dimethyl sulfoxide
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Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: Understanding the Concept:
Purine catabolism culminates in the oxidation of hypoxanthine and xanthine to uric acid, catalyzed by the enzyme xanthine oxidase.
Step 2: Detailed Explanation:
1. Allopurinol is a structural isomer of hypoxanthine.
2. It acts as a potent competitive inhibitor of xanthine oxidase.
3. Upon binding, xanthine oxidase oxidizes allopurinol to Alloxanthine (oxypurinol), which remains tightly bound to the enzyme's active site, acting as a suicide/non-competitive inhibitor.
4. This blocks the conversion of purines to uric acid, reducing blood uric acid levels.
It is widely used clinically to treat hyperuricemia and gout. Cyclo-oxygenase and lipo-oxygenase are involved in arachidonic acid metabolism.
Step 3: Final Answer:
The correct option is 3, which corresponds to Allopurinol.
Purine catabolism culminates in the oxidation of hypoxanthine and xanthine to uric acid, catalyzed by the enzyme xanthine oxidase.
Step 2: Detailed Explanation:
1. Allopurinol is a structural isomer of hypoxanthine.
2. It acts as a potent competitive inhibitor of xanthine oxidase.
3. Upon binding, xanthine oxidase oxidizes allopurinol to Alloxanthine (oxypurinol), which remains tightly bound to the enzyme's active site, acting as a suicide/non-competitive inhibitor.
4. This blocks the conversion of purines to uric acid, reducing blood uric acid levels.
It is widely used clinically to treat hyperuricemia and gout. Cyclo-oxygenase and lipo-oxygenase are involved in arachidonic acid metabolism.
Step 3: Final Answer:
The correct option is 3, which corresponds to Allopurinol.
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