Question

Which of the following tests is not required for sustained and modified release tablets?

• A. Hardness
• B. Friability
• C. Disintegration
• D. Dissolution

Hint:

SR tablets shouldn't break (disintegrate); they should slowly melt (dissolve).

Answer 1

The Correct Option is C

Step 1: Concept
Quality control tests for tablets ensure they meet pharmacopoeial standards. Standard tests include hardness, friability, weight variation, disintegration, and dissolution.

Step 2: Meaning
The disintegration test measures the time it takes for a tablet to break into small particles.

Step 3: Analysis
Sustained-release (SR) and modified-release tablets are designed to stay intact and slowly release the drug over a long period. Since they are intended not to break down immediately, a disintegration test (which usually looks for breakdown within 15–60 minutes) is irrelevant and not required. Instead, the dissolution test is the critical measure for these tablets.

Step 4: Conclusion
Therefore, the disintegration test is not applicable to sustained-release dosage forms.

Final Answer: (C)