Question:
Which of the following statements are not correct about first order kinetics?
(A). Clearance remains constant
(B). Fixed amount of the drug is eliminated
(C). Half-life increases with dose
(D). Decrease in clearance with increasing dose
Choose the correct answer from the options given below:
Which of the following statements are not correct about first order kinetics?
(A). Clearance remains constant
(B). Fixed amount of the drug is eliminated
(C). Half-life increases with dose
(D). Decrease in clearance with increasing dose
Choose the correct answer from the options given below:
(A). Clearance remains constant
(B). Fixed amount of the drug is eliminated
(C). Half-life increases with dose
(D). Decrease in clearance with increasing dose
Choose the correct answer from the options given below:
Show Hint
First-order kinetics: Constant fraction eliminated, Clearance and Half-life are constant.
Zero-order kinetics: Constant amount eliminated, Clearance decreases and Half-life increases with dose.
Zero-order kinetics: Constant amount eliminated, Clearance decreases and Half-life increases with dose.
Updated On: Jul 14, 2026
- (A), (B) and (D) only.
- (C) and (D) only.
- (B), (C) and (D) only.
- (A) and (D) only.
Show Solution
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The Correct Option is C
Solution and Explanation
Step 1: Understanding the Concept:
In first-order kinetics, the rate of drug elimination is directly proportional to the plasma concentration of the drug.
A constant *fraction* of the drug is eliminated per unit of time.
Detailed Explanation:
Let us analyze each statement for first-order kinetics:
- Statement (A): Clearance ($Cl = V_d \times k_{el}$) is independent of concentration and dose, meaning it remains constant. This statement is CORRECT.
- Statement (B): A fixed *fraction* (percentage) of the drug is eliminated per unit time, not a fixed *amount*.
A fixed *amount* is eliminated in zero-order kinetics (saturated pathways). This statement is INCORRECT.
- Statement (C): The half-life ($t_{1/2}$) of the drug is constant and independent of the administered dose. This statement is INCORRECT.
- Statement (D): Since clearance is constant, it does not decrease with an increase in dose. This statement is INCORRECT.
Therefore, statements (B), (C), and (D) are not correct about first-order kinetics.
Step 2: Final Answer:
The correct option is (C).
In first-order kinetics, the rate of drug elimination is directly proportional to the plasma concentration of the drug.
A constant *fraction* of the drug is eliminated per unit of time.
Detailed Explanation:
Let us analyze each statement for first-order kinetics:
- Statement (A): Clearance ($Cl = V_d \times k_{el}$) is independent of concentration and dose, meaning it remains constant. This statement is CORRECT.
- Statement (B): A fixed *fraction* (percentage) of the drug is eliminated per unit time, not a fixed *amount*.
A fixed *amount* is eliminated in zero-order kinetics (saturated pathways). This statement is INCORRECT.
- Statement (C): The half-life ($t_{1/2}$) of the drug is constant and independent of the administered dose. This statement is INCORRECT.
- Statement (D): Since clearance is constant, it does not decrease with an increase in dose. This statement is INCORRECT.
Therefore, statements (B), (C), and (D) are not correct about first-order kinetics.
Step 2: Final Answer:
The correct option is (C).
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