Question:
Which of the following is not true about the denaturation of protein?
Which of the following is not true about the denaturation of protein?
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Denaturation destroys secondary, tertiary, and sometimes quaternary structures, but the primary structure usually remains intact because peptide bonds are not broken.
Updated On: Jun 26, 2026
- \(2^\circ\) structure gets destroyed
- \(3^\circ\) structure gets destroyed
- \(1^\circ\) structure gets destroyed
- Bioactivity is lost
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The Correct Option is C
Solution and Explanation
Step 1: Understand denaturation of proteins.
Denaturation is the process in which the natural structure of a protein is altered due to heat, acids, bases, alcohol, heavy metal ions, or other agents.
As a result, the protein loses its biological activity.
Step 2: Examine the primary structure.
The primary structure of a protein refers to the amino acid sequence connected through peptide bonds.
During denaturation, peptide bonds are generally not broken.
Therefore, the primary structure remains unchanged.
Step 3: Examine secondary and tertiary structures.
Secondary structure depends on hydrogen bonding.
Tertiary structure depends on hydrogen bonds, ionic interactions, hydrophobic interactions, and other weak forces.
These interactions are disrupted during denaturation.
Hence, \[ 2^\circ \] and \[ 3^\circ \] structures are destroyed.
Step 4: Effect on biological activity.
Because the three-dimensional shape is altered, the protein can no longer perform its biological function properly.
Thus, bioactivity is lost.
Step 5: Final conclusion.
The statement that is not true is: \[ \boxed{\text{Primary structure gets destroyed}} \] Therefore, the correct option is \[ \boxed{(3)} \]
Denaturation is the process in which the natural structure of a protein is altered due to heat, acids, bases, alcohol, heavy metal ions, or other agents.
As a result, the protein loses its biological activity.
Step 2: Examine the primary structure.
The primary structure of a protein refers to the amino acid sequence connected through peptide bonds.
During denaturation, peptide bonds are generally not broken.
Therefore, the primary structure remains unchanged.
Step 3: Examine secondary and tertiary structures.
Secondary structure depends on hydrogen bonding.
Tertiary structure depends on hydrogen bonds, ionic interactions, hydrophobic interactions, and other weak forces.
These interactions are disrupted during denaturation.
Hence, \[ 2^\circ \] and \[ 3^\circ \] structures are destroyed.
Step 4: Effect on biological activity.
Because the three-dimensional shape is altered, the protein can no longer perform its biological function properly.
Thus, bioactivity is lost.
Step 5: Final conclusion.
The statement that is not true is: \[ \boxed{\text{Primary structure gets destroyed}} \] Therefore, the correct option is \[ \boxed{(3)} \]
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