Step 1: Understanding the Concept:
Different enzymes have different requirements for initiation.
Some require primers, others do not.
Step 2: Key Formula or Approach:
No specific formula.
Need to know the primer requirements of enzymes.
Step 3: Detailed Explanation:
DNA polymerases (Pol I, Pol II) require a primer.
Reverse transcriptase requires a primer.
RNA polymerase does NOT require a primer.
It initiates transcription de novo.
Thus, RNA polymerase does not require a primer.
Step 4: Final Answer:
RNA polymerase does NOT require a primer.
Hence, the correct option is (C).