Question:
Which is not a protecting group for amine in peptide synthesis?
Which is not a protecting group for amine in peptide synthesis?
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Recall the standard carbamate based amine protecting groups used in peptide synthesis.
Updated On: Jul 3, 2026
- CBz
- FMoc
- Boc
- Methyl
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The Correct Option is D
Solution and Explanation
Step 1: Boc, Cbz, and Fmoc form carbamate linkages with amine nitrogen, selectively removable later.
Step 2: A plain methyl group on nitrogen is not reversible under mild conditions, so not a genuine protecting group. Methyl is instead used to protect the carboxylic acid end as a methyl ester.
\[\boxed{(D)\ Methyl}\]Was this answer helpful?
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