Question:
Which from following buffers is used as highly effective stabilizer in the preparation of penicillin?
Which from following buffers is used as highly effective stabilizer in the preparation of penicillin?
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Penicillin is stabilised with a citrate buffer.
Updated On: Nov 12, 2026
- Ammonium hydroxide and ammonium chloride
- Acetic acid and sodium acetate
- Formic acid and sodium acetate
- Citric acid and sodium citrate
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The Correct Option is D
Solution and Explanation
Step 1: Understanding the Concept
Penicillin breaks down in strongly acidic or basic conditions, so a buffer is used to hold the pH in a narrow range.
Step 2: Recall the buffer
Industrial preparations of penicillin use a buffer made of citric acid and sodium citrate.
Step 3: Conclusion
So the stabiliser is the citric acid and sodium citrate buffer.
Final Answer:
A citric acid and sodium citrate buffer stabilises penicillin. \[ \boxed{\text{(D) }\text{Citric acid and sodium citrate}} \]
Penicillin breaks down in strongly acidic or basic conditions, so a buffer is used to hold the pH in a narrow range.
Step 2: Recall the buffer
Industrial preparations of penicillin use a buffer made of citric acid and sodium citrate.
Step 3: Conclusion
So the stabiliser is the citric acid and sodium citrate buffer.
Final Answer:
A citric acid and sodium citrate buffer stabilises penicillin. \[ \boxed{\text{(D) }\text{Citric acid and sodium citrate}} \]
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