Question

Which excipient is most unsuitable in nasal insufflations due to mucosal irritation?

• A. Lactose
• B. Dextrose
• C. Talc
• D. Starch

Hint:

Talc should be avoided in nasal insufflations because it can irritate the nasal mucosa.

Answer 1

The Correct Option is C

Concept:
Nasal insufflations are powder preparations administered into the nasal cavity.

Step 1: Requirement of nasal excipients.
Excipients used in nasal preparations should be non-irritating and safe for nasal mucosa.

Step 2: Problem with talc.
Talc is insoluble and may irritate mucosal surfaces. It is not suitable for nasal insufflations.

Step 3: Other excipients.
Lactose, dextrose, and starch are comparatively more acceptable as diluents in some powder formulations.

Step 4: Final answer.
Hence, talc is most unsuitable due to mucosal irritation. \[ \boxed{\text{Talc}} \]