Question

A drug meant for immediate nasal absorption must be formulated to be _______

• A. Hypotonic
• B. Hypertonic
• C. Isotonic
• D. Acidic

Hint:

Nasal preparations should preferably be isotonic to avoid irritation and improve patient comfort.

Answer 1

The Correct Option is C

Concept:
Nasal preparations should be comfortable and non-irritating to the nasal mucosa.

Step 1: Meaning of isotonic.
An isotonic solution has osmotic pressure similar to body fluids. It does not cause irritation or damage to mucosal tissues.

Step 2: Importance in nasal absorption.
For immediate nasal absorption, the formulation must remain in contact with the nasal mucosa without causing irritation or excessive secretion.

Step 3: Why other options are wrong.
Hypotonic and hypertonic solutions may cause irritation.
Acidic formulation may irritate the nasal mucosa and reduce patient comfort.

Step 4: Final answer.
Therefore, the drug should be formulated as isotonic. \[ \boxed{\text{Isotonic}} \]