Question:
Which enzyme acts as “molecular glue” to join DNA fragments?
Which enzyme acts as “molecular glue” to join DNA fragments?
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DNA ligase is essential in DNA replication (joining Okazaki fragments) and in genetic engineering for creating recombinant DNA molecules.
Updated On: Apr 22, 2026
- DNA Polymerase
- DNA Ligase
- Helicase
- Restriction Endonuclease
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The Correct Option is B
Solution and Explanation
Concept:
DNA ligase is an enzyme that joins DNA fragments by forming phosphodiester bonds between adjacent nucleotides. It is commonly referred to as “molecular glue”.
Step 1: Understand its function.
DNA ligase seals nicks in the DNA backbone during replication and repair.
Step 2: Role in recombinant DNA technology.
It is used to join DNA fragments cut by restriction enzymes, enabling the formation of recombinant DNA.
Step 3: Conclusion.
Thus, DNA ligase acts as the molecular glue that joins DNA fragments. \[ \boxed{\text{DNA Ligase}} \]
DNA ligase is an enzyme that joins DNA fragments by forming phosphodiester bonds between adjacent nucleotides. It is commonly referred to as “molecular glue”.
Step 1: Understand its function.
DNA ligase seals nicks in the DNA backbone during replication and repair.
Step 2: Role in recombinant DNA technology.
It is used to join DNA fragments cut by restriction enzymes, enabling the formation of recombinant DNA.
Step 3: Conclusion.
Thus, DNA ligase acts as the molecular glue that joins DNA fragments. \[ \boxed{\text{DNA Ligase}} \]
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