Question:
Which drug produces Reactive Oxygen Species (ROS) in microbial cells leading to DNA damage
Which drug produces Reactive Oxygen Species (ROS) in microbial cells leading to DNA damage
Show Hint
Metronidazole "Metro-nukes" DNA via free radicals in anaerobic environments.
Updated On: May 15, 2026
- Albendazole
- Thiabendazole
- Metronidazole
- Nitazoxanide
Show Solution
Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: Concept
Metronidazole is a nitroimidazole used against anaerobic bacteria and protozoa.
Step 2: Meaning
ROS are chemically reactive chemical species containing oxygen that damage cellular components like DNA.
Step 3: Analysis
Inside anaerobic organisms, the nitro group of Metronidazole is reduced by the pyruvate-ferredoxin oxidoreductase system. This reduction produces unstable, reactive intermediates (free radicals).
Step 4: Conclusion
These radicals and ROS cause DNA strand breakage and cell death. Final Answer: (C)
Was this answer helpful?
0
0
Top GPAT Pharmacology Questions
- Ethylketazocine is a 6,7‐benzomorphan derivative with _____ receptor selectivity.
- Which of the following is NOT a cause for the drug undergoing nonlinear pharmacokinetics
- Match List I with List II
List I-Drugs List II-Classes A Anakinra I IL‐2 receptor antagonist B Basiliximab II TNFα inhibitors C Infliximab III Calcineurin inhibitors D Tacrolimus IV mTOR inhibitors E - V IL‐1 receptor antagonist Choose the correct answer from the options given below:
- The ‘Up‐and‐Down’ method for a projected LD50 determination is described in the…..
- Match List I with List II
List I-(Poisoning) List II-(Treatment) A Warfarin I Pralidoxime B Carbon monoxide II Oxygen C Cyanide III Vitamin K D Nitrites IV Dicobalt edatate E Organophosphates V Methylene blue
Choose the correct answer from the options given below:
View More Questions
Top GPAT Chemotherapy Questions
- Identify the drug which is not useful in the treatment of tuberculosis:
- Which of the following is NOT a gene associated with breast cancer?
- Glycosides are condensation products of
- Vinca alkaloids that are used in combination therapy to treat a variety of tumors. How to cancer cells normally gain resistance to these agents
- Which of the following is not a sulphonamide derivative?
View More Questions
Top GPAT Questions
- Match the symbols in the List I with the terms used in the List II of conductance measurements, and
List I
SymbolsList II
TermsA \(\Omega^{-1}\) I Specific conductance B \(∧\) II Electrical conductance C k III Specific resistance D \(\rho\) IV Equivalent conductance
Choose the correct answer from the options given below: - Cottrell’s method is used for the measurement of:
- Match the statements in List I with their correct answers in List II, respectively, in respect to modified 1st law of thermodynamics, and
List I
List II
A Constant heat (q = 0) I Isothermal B Reversible process at constant temperature (dT = 0) II Isometric C Constant volume (dV = 0) III Adiabatic D Constant pressure (dP = 0) IV Isobar
Choose the correct answer from the options given below: - Boric acid with molecular weight 61.83 was partitioned between water and amyl alcohol at 25 °C. The amount of boric acid was determined to be 0.24 g in 250 ml of amyl alcohol and 0.32 g in 100 ml water. The partition coefficient of boric acid between water and amyl alcohol, when calculated at molar concentration for each of the solution, is:
- Drugs ‘A’, ‘B’ and ‘C’ follow zero order, first order and second order degradation kinetics, respectively, but have the same rate constant. Which of the following statement is true in this respect:
View More Questions