Question

Which database contains 3D structures of biomolecules?

• A. GenBank
• B. Swiss-Prot
• C. Protein Data Bank
• D. EMBL

Hint:

Remember the most important biological databases: \[ \boxed{ \begin{aligned} \text{GenBank/EMBL/DDBJ} &\rightarrow \text{DNA Sequences} \\ \text{Swiss-Prot} &\rightarrow \text{Protein Sequences} \\ \textbf{PDB} &\rightarrow \textbf{3D Structures} \end{aligned} } \] PDB is the standard database for protein and nucleic acid structures.

Answer 1

The Correct Option is C

Concept: The Protein Data Bank (PDB) is the world's primary repository for three-dimensional structural data of biological macromolecules. Structures deposited in PDB are determined experimentally using techniques such as X-ray crystallography, Nuclear Magnetic Resonance (NMR) spectroscopy, and Cryo-Electron Microscopy (Cryo-EM).

Step 1: Understand the Protein Data Bank.
PDB stores structural information for:
• Proteins
• DNA
• RNA
• Protein-DNA complexes
• Protein-ligand complexes Each deposited structure receives a unique four-character PDB identification code.

Step 2: Importance of PDB.
Scientists use PDB data for:
• Drug discovery
• Protein engineering
• Molecular docking
• Structural biology
• Bioinformatics research The database enables visualization and analysis of biomolecular structures.

Step 3: Eliminate incorrect options.

• GenBank stores nucleotide sequences.
• EMBL stores nucleotide sequence data.
• Swiss-Prot stores curated protein sequence information.
• Only Protein Data Bank contains experimentally determined three-dimensional structures. Final Answer: \[ \boxed{Option (C) is correct \]