Question

Which among the following contribute to the autoimmune disorder Myasthenia gravis?

• A. T Cells
• B. Macrophages
• C. Antibodies
• D. Interleukins

Hint:

Remember:
• Myasthenia gravis $\rightarrow$ Autoantibodies against acetylcholine receptors.
• Rheumatoid arthritis $\rightarrow$ Autoimmune attack on joints.
• Type 1 Diabetes $\rightarrow$ Autoimmune destruction of pancreatic $\beta$-cells.

Answer 1

The Correct Option is C

Concept: Myasthenia gravis is an autoimmune disorder in which the body's immune system mistakenly produces antibodies against its own acetylcholine receptors present at the neuromuscular junction. These antibodies block nerve impulse transmission, resulting in muscle weakness and fatigue.
• It is an autoimmune disease.
• Autoantibodies attack acetylcholine receptors on skeletal muscles.
• The reduced number of functional receptors prevents effective muscle contraction.
• Patients experience muscle weakness, drooping eyelids, double vision and fatigue.

Step 1: Understand the cause of Myasthenia gravis.
Normally, acetylcholine released from motor neurons binds to receptors on muscle cells and initiates muscle contraction. In Myasthenia gravis, antibodies bind to these receptors and either block or destroy them. \[ \boxed{\text{Autoantibodies} \longrightarrow \text{Blocked ACh receptors} \longrightarrow \text{Muscle weakness}} \]

Step 2: Identify the responsible immune component.
Although T cells participate in regulating immune responses, the direct cause of Myasthenia gravis is the production of pathogenic antibodies by B cells. These antibodies interfere with neuromuscular transmission and produce the characteristic symptoms.

Step 3: Choose the correct option.
Among the given options, antibodies are directly responsible for the disease mechanism. \[ \boxed{Option (C) is the correct answer. \]