Question:
Type I hyperlipoproteinemia is characterized by which of the following?
Type I hyperlipoproteinemia is characterized by which of the following?
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Lipoprotein lipase deficiency leaves chylomicrons uncleared.
Updated On: Jun 24, 2026
- Elevated LDL
- Elevated HDL
- Elevated chylomicrons
- Elevated lipoprotein lipase
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The Correct Option is C
Solution and Explanation
Step 1: Type I hyperlipoproteinemia is caused by a deficiency of the enzyme lipoprotein lipase (or its cofactor apo C-II), which normally clears triglyceride-rich particles from blood.
Step 2: Because chylomicrons cannot be broken down, they accumulate, producing very high triglyceride levels. The hallmark is therefore elevated chylomicrons.
Step 3: The enzyme itself is deficient, so option d (elevated lipoprotein lipase) is wrong; LDL and HDL elevations are not the defining feature of this autosomal recessive disorder.
Step 4: Clinically it presents in infancy with colicky abdominal pain, failure to thrive, and eruptive xanthomas, and is managed by restricting dietary fat. The correct answer is elevated chylomicrons.
Step 2: Because chylomicrons cannot be broken down, they accumulate, producing very high triglyceride levels. The hallmark is therefore elevated chylomicrons.
Step 3: The enzyme itself is deficient, so option d (elevated lipoprotein lipase) is wrong; LDL and HDL elevations are not the defining feature of this autosomal recessive disorder.
Step 4: Clinically it presents in infancy with colicky abdominal pain, failure to thrive, and eruptive xanthomas, and is managed by restricting dietary fat. The correct answer is elevated chylomicrons.
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