Question:
Regarding apoprotein-C, which of the following is true?
Regarding apoprotein-C, which of the following is true?
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Apo C-II activates LPL, apo C-III inhibits it, and apo C rides on triglyceride-rich lipoproteins.
Updated On: Jun 24, 2026
- Activates lipoprotein lipase
- Inactivates lipoprotein lipase
- Facilitates triglyceride transport
- All of the above
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The Correct Option is D
Solution and Explanation
Step 1: Apoprotein C exists in subtypes that have opposing effects on lipoprotein lipase (LPL), the enzyme that hydrolyses triglycerides in plasma.
Step 2: Apo C-II is an essential activator of lipoprotein lipase. In contrast, apo C-III (along with apo A-II) acts as an inhibitor of lipoprotein lipase. So the apo C family includes both an activator and an inhibitor of the enzyme.
Step 3: Apo C is a structural component of chylomicrons and VLDL, the triglyceride-rich lipoproteins. By being part of these particles it facilitates the transport of triglycerides in the blood.
Step 4: Since apoprotein C can activate LPL (apo C-II), inactivate LPL (apo C-III), and facilitate triglyceride transport, all three statements are correct. Hence the answer is all of the above.
Step 2: Apo C-II is an essential activator of lipoprotein lipase. In contrast, apo C-III (along with apo A-II) acts as an inhibitor of lipoprotein lipase. So the apo C family includes both an activator and an inhibitor of the enzyme.
Step 3: Apo C is a structural component of chylomicrons and VLDL, the triglyceride-rich lipoproteins. By being part of these particles it facilitates the transport of triglycerides in the blood.
Step 4: Since apoprotein C can activate LPL (apo C-II), inactivate LPL (apo C-III), and facilitate triglyceride transport, all three statements are correct. Hence the answer is all of the above.
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