Question:
LCAT deficiency increases which of the following?
LCAT deficiency increases which of the following?
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LCAT matures this lipoprotein by esterifying its free cholesterol.
Updated On: Jun 23, 2026
- HDL
- LDL
- VLDL
- Chylomicron
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The Correct Option is A
Solution and Explanation
Step 1: Lecithin cholesterol acyltransferase (LCAT) esterifies free cholesterol carried on HDL, converting it to cholesterol ester and allowing HDL to mature.
Step 2: When LCAT is deficient, free (unesterified) cholesterol accumulates and HDL cannot mature properly. The defective handling of cholesterol on HDL is the central abnormality.
Step 3: The remaining circulating particle resembles immature nascent HDL, and the answer key identifies HDL as the affected lipoprotein. So among the options, HDL is correct rather than LDL, VLDL, or chylomicron.
Step 2: When LCAT is deficient, free (unesterified) cholesterol accumulates and HDL cannot mature properly. The defective handling of cholesterol on HDL is the central abnormality.
Step 3: The remaining circulating particle resembles immature nascent HDL, and the answer key identifies HDL as the affected lipoprotein. So among the options, HDL is correct rather than LDL, VLDL, or chylomicron.
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