Question

Trilene (trichloroethylene) is degraded by:

• A. Enzymatic degradation
• B. Non-enzymatic degradation
• C. Chemical degradation
• D. None

Hint:

Trichloroethylene metabolism starts with a dioxygenase enzyme.

Answer 1

The Correct Option is A

Step 1: Trilene (trichloroethylene) is an inhalational agent that is a good analgesic, non-flammable and less depressant, but it must not be used in a closed circuit because it reacts with soda-lime to release toxic phosgene. Step 2: Its metabolic breakdown in the body is carried out enzymatically. The pathway is initiated by the enzyme toluene 1,2-dioxygenase, confirming this is an enzyme-driven process. Step 3: The reactive intermediate, trichloroethylene epoxide, then breaks down to products such as dichloroacetate, carbon monoxide, glyoxylate and formate. Step 4: Because the degradation is started and controlled by enzymes, option a (enzymatic degradation) is correct; the non-enzymatic and chemical options do not describe the primary metabolic route.