Question

"Tram-line" intracranial calcifications seen on imaging are characteristic of which of the following conditions?

• A. Treacher Collins syndrome
• B. Sturge-Weber syndrome
• C. Tuberous sclerosis
• D. Neurofibromatosis type 1

Hint:

Tram-line or gyriform intracranial calcifications on imaging are a classic radiological sign of Sturge-Weber syndrome.

Answer 1

The Correct Option is B

Step 1: Understanding “Tram-line” Calcifications.
“Tram-line” calcifications refer to parallel, linear intracranial calcifications seen on radiographs or CT scansThese calcifications typically follow the contours of cerebral gyri and appear as double-lined densities resembling tram tracks
Step 2: Association with Sturge-Weber Syndrome.
Sturge-Weber syndrome is a neurocutaneous disorder characterized by facial port-wine stain (nevus flammeus), leptomeningeal angiomas, and intracranial calcificationsThe calcifications are typically gyriform and produce the classical tram-line appearance on imaging
Step 3: Evaluation of Other Options.
(A) Treacher Collins syndrome: A craniofacial developmental disorder without characteristic intracranial tram-line calcifications
(B) Sturge-Weber syndrome: CorrectClassically associated with tram-line or gyriform intracranial calcifications
(C) Tuberous sclerosis: Shows cortical tubers and subependymal calcifications, not tram-line pattern
(D) Neurofibromatosis type 1: Characterized by café-au-lait spots and neurofibromas, not tram-line calcifications
Step 4: Conclusion.
Therefore, tram-line intracranial calcifications are characteristic of Sturge-Weber syndrome