Question

The selection of cells whose T-cell receptors respond to self-MHC is known as:

• A. Negative selection
• B. MHC restriction
• C. Affinity maturation
• D. Lineage commitment

Hint:

MHC Restriction = T-cells must recognize "Self" MHC.

Answer 1

The Correct Option is B

Step 1: Concept
T-cell development in the thymus involves rigorous testing to ensure T-cells are functional but not dangerous.

Step 2: Meaning
Positive selection (leading to MHC restriction) ensures T-cells can recognize the host's MHC molecules.

Step 3: Analysis
A T-cell that cannot bind to the body's MHC molecules is useless. The process that ensures a T-cell only responds to peptides presented by self-MHC is MHC restriction. Negative selection, by contrast, removes T-cells that bind *too* strongly to self-peptides.

Step 4: Conclusion
MHC restriction describes the requirement for T-cells to recognize self-MHC. Final Answer: (B)