Question:
The release of drug from cellulose acetate phthalate is due to
The release of drug from cellulose acetate phthalate is due to
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Enteric polymers protect acid-labile drugs or prevent stomach irritation by the drug.
Updated On: Jun 15, 2026
- pH independent solubility
- pH dependent solubility
- Release of drug due to erosion
- Zero order release
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The Correct Option is B
Solution and Explanation
Step 1: Understanding the Concept:
Cellulose acetate phthalate (CAP) is a widely used enteric coating polymer.
Step 2: Detailed Explanation:
CAP contains free carboxylic acid groups that are insoluble in the acidic environment of the stomach (low pH).
As the dosage form moves to the small intestine, the higher pH (above 6.0) causes the ionization of these carboxyl groups.
This ionization makes the polymer soluble, allowing the coating to dissolve and release the drug specifically in the intestine.
Step 3: Final Answer:
The mechanism of release is based on pH-dependent solubility.
Cellulose acetate phthalate (CAP) is a widely used enteric coating polymer.
Step 2: Detailed Explanation:
CAP contains free carboxylic acid groups that are insoluble in the acidic environment of the stomach (low pH).
As the dosage form moves to the small intestine, the higher pH (above 6.0) causes the ionization of these carboxyl groups.
This ionization makes the polymer soluble, allowing the coating to dissolve and release the drug specifically in the intestine.
Step 3: Final Answer:
The mechanism of release is based on pH-dependent solubility.
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