Question

By coating the granules with water insoluble polymer, one can achieve the release of drug as per

• A. Zero order rate
• B. First order rate
• C. Half order rate
• D. Pseudo First order rate

Hint:

Zero-order release kinetics are ideal for maintaining steady-state plasma concentrations of a drug.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
Controlled release dosage forms are designed to release drug at a constant rate over time, known as zero-order kinetics.

Step 2: Detailed Explanation:
When granules are coated with a water-insoluble, permeable polymer (like ethylcellulose), the polymer acts as a rate-controlling membrane.
The drug diffuses through this membrane at a constant rate, independent of the remaining concentration of the drug within the core.
This maintenance of a constant release rate is the hallmark of zero-order delivery systems.

Step 3: Final Answer:
Coating with water-insoluble polymers primarily aims to achieve a zero-order release rate.