Question

In transdermal therapeutic systems the most commonly used penetration enhancer is

• A. Glycerin
• B. Propyl Glycol
• C. Dimethyl sulfoxide
• D. Lanolin

Hint:

Penetration enhancers work by modifying skin lipids, denaturing proteins, or improving drug solubility.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Penetration enhancers are substances that increase the permeability of the skin to allow for the absorption of drug molecules.

Step 2: Detailed Explanation:
Dimethyl sulfoxide (DMSO) is a potent solvent and one of the most widely studied chemical penetration enhancers.
It works by disrupting the lipid structure of the stratum corneum, thereby lowering the barrier function and facilitating drug transport.
While others like propylene glycol can act as solvents, DMSO is classically recognized in pharmacological texts for its significant enhancement properties.

Step 3: Final Answer:
Dimethyl sulfoxide is considered a commonly used and highly effective penetration enhancer.