Question

The affinity of hemoglobin for oxygen is increased by:

• A. 2 times
• B. 25-fold
• C. 250 fold
• D. No change

Hint:

Hemoglobin affinity:
Increased by high pH, low temperature, low 2,3-BPG.
Bohr effect: pH effect on oxygen binding.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
Hemoglobin's affinity for oxygen is modulated by various factors.
Certain substances increase its affinity.

Step 2: Key Formula or Approach:
No specific formula.
Need to know the factors affecting hemoglobin affinity.

Step 3: Detailed Explanation:
The affinity of hemoglobin for oxygen is increased by:
- Decrease in temperature
- Decrease in 2,3-BPG
- Increase in pH (Bohr effect)
The increase is about 25-fold.
Thus, the affinity can be increased 25-fold.

Step 4: Final Answer:
The affinity of hemoglobin for oxygen is increased by 25-fold.
Hence, the correct option is (B).