Question

Symptoms of an allergy attack can be prevented by

• A. Reducing the number of helper T cells in the body
• B. Blocking the attachment of the IgE antibodies to the mast cells
• C. Blocking the attachment of cytotoxic cells to dendritic cells
• D. Reducing the number of natural killer cells

Hint:

• Allergy = IgE + Mast cells
• Block IgE binding → Prevent histamine release

Answer 1

The Correct Option is B

Concept: Allergic reactions (Type I hypersensitivity) are mediated by IgE antibodies bound to mast cells.
• IgE binds to Fc receptors on mast cells
• Allergen binding triggers mast cell degranulation
• Leads to release of histamine → allergy symptoms

Step 1: Understanding prevention strategy.

• Preventing IgE from binding to mast cells blocks the allergic response at an early stage

Step 2: Analyzing options.

• Helper T cells: Important in immunity but not direct target → Incorrect.
• IgE–mast cell interaction: Key step in allergy → Correct.
• Cytotoxic–dendritic interaction: Not relevant → Incorrect.
• Natural killer cells: Not involved in allergy → Incorrect.

Step 3: Selecting the correct answer.
Thus, blocking IgE binding to mast cells prevents allergy symptoms.