Question

Sickle cell anemia is this mutation and occurs due to change of these amino acids.

• A. Somatic mutations : Alanine → Valine
• B. Point mutations : Glutamate → Valine
• C. Deletion mutations : Valine → Alanine
• D. Frame shift mutations : Glycine → Serine

Hint:

Remember: Sickle cell = GAG → GTG = Glutamate to Valine (point mutation).

Answer 1

The Correct Option is B

Sickle cell anemia is caused by a point mutation in the $\beta$-globin gene of hemoglobin, where the codon GAG (glutamate) is mutated to GTG (valine). This single base substitution changes the amino acid and leads to the disease.