Question:
Reed-Sternberg cells are found in which condition?
Reed-Sternberg cells are found in which condition?
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Owl's eye RS cells (CD30+, CD15+) are pathognomonic of Hodgkin's lymphoma.
Updated On: Jun 23, 2026
- Hodgkin's disease
- Sickle cell anaemia
- Thalassemia
- CML
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The Correct Option is A
Solution and Explanation
Step 1: Reed-Sternberg (RS) cells are large, derived from germinal-center B lymphocytes, and are the hallmark of Hodgkin's lymphoma (Hodgkin's disease), so option a is correct.
Step 2: Morphologically RS cells are multinucleated or have a bilobed nucleus with prominent eosinophilic nucleoli, producing the classic "owl's eye" appearance against a reactive background.
Step 3: Immunophenotype: RS cells are CD30 and CD15 positive and usually negative for CD20 and CD45, helping distinguish Hodgkin from non-Hodgkin lymphoma.
Step 4: Options b (sickle cell anaemia), c (thalassemia) and d (CML) are red-cell or myeloid disorders that have no association with RS cells, so they are excluded.
Step 2: Morphologically RS cells are multinucleated or have a bilobed nucleus with prominent eosinophilic nucleoli, producing the classic "owl's eye" appearance against a reactive background.
Step 3: Immunophenotype: RS cells are CD30 and CD15 positive and usually negative for CD20 and CD45, helping distinguish Hodgkin from non-Hodgkin lymphoma.
Step 4: Options b (sickle cell anaemia), c (thalassemia) and d (CML) are red-cell or myeloid disorders that have no association with RS cells, so they are excluded.
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