Question:
H and L variety cells are seen in which type of Hodgkin lymphoma?
H and L variety cells are seen in which type of Hodgkin lymphoma?
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L and H popcorn cells are the hallmark of nodular lymphocyte-predominant Hodgkin lymphoma.
Updated On: Jun 23, 2026
- Mixed cellularity Hodgkin
- Lymphocyte depleted
- Lymphocyte predominance
- Nodular sclerosis
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The Correct Option is C
Solution and Explanation
Step 1: Hodgkin lymphoma is split into two broad entities - classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Step 2: The defining cell differs between them. Classical Hodgkin lymphoma contains classic Reed-Sternberg cells (HRS cells). Step 3: NLPHL instead contains lymphocytic and histiocytic cells, the so-called L and H cells (also described as popcorn cells), which are the variant Reed-Sternberg cells of this subtype. Step 4: Mixed cellularity, lymphocyte depleted and nodular sclerosis are all subtypes of the classical group and show classic HRS cells, not L and H cells. Therefore the H and L variety is the marker of the lymphocyte predominance subtype.
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