Question

Quantity of tablets required for friability test as per Indian Pharmacopoeia is

• A. no. of tablets equivalent to 6.5 grams weight if the tablet weight is less than 650 mg
• B. no. of tablets equivalent to 3.25 grams weight if the tablet weight is less than 650 mg
• C. 10 tablets irrespective of weight of tablets
• D. 20 tablets irrespective of weight of tablets

Hint:

Friability Rule: < 650 mg tablet = 6.5g sample. > 650 mg tablet = 10 tablets.

Answer 1

The Correct Option is A

Step 1: Concept
Friability testing measures the resistance of tablets to chipping, crumbling, or breaking during handling and transport.

Step 2: Meaning
The IP and USP provide specific sampling protocols based on the individual weight of the tablet.

Step 3: Analysis
For tablets with a unit weight equal to or less than 650 mg, a sample of whole tablets corresponding to about 6.5 g is taken. If the tablet weighs more than 650 mg, 10 whole tablets are used.

Step 4: Conclusion
Thus, the required quantity for tablets under 650 mg is a sample totaling approximately 6.5 grams.

Final Answer: (A)