Question

One of the following drugs is not meant for systemic use:

• A. Netilmycin
• B. Sisomiein
• C. Neomycin
• D. Paramomycin

Answer 1

The Correct Option is C

To determine which of the listed drugs is not meant for systemic use, we need to understand the application and administration routes of each antibiotic.

1. Netilmycin: This is an aminoglycoside antibiotic used to treat various types of bacterial infections. It is usually administered intravenously or intramuscularly, indicating its systemic use.
2. Sisomiein: It appears to be a typo or a variation that might refer to a similar aminoglycoside antibiotic. Aminoglycosides in general are used systemically for severe infections.
3. Neomycin: This antibiotic is mainly used for topical applications or sometimes orally for bowel decontamination before surgery. It is not absorbed well into the bloodstream when taken orally, and therefore, is not typically used for systemic infections due to its high nephrotoxicity and ototoxicity.
4. Paramomycin: Also known as Paromomycin, this is an aminoglycoside antibiotic used to treat intestinal infections and certain parasites and is sometimes used for intramuscular administration for systemic applications.

The correct answer is Neomycin, as it is predominantly used for topical infections and bowel cleaning, thus unsuitable for systemic use due to potential toxicity if absorbed in significant amounts.