Question:
Nitrodisc is an example of which type of Drug Delivery System?
Nitrodisc is an example of which type of Drug Delivery System?
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Transdermal patches like Nitrodisc ensure steady plasma drug levels and are useful in chronic conditions like angina, hypertension, and hormone replacement therapy.
Updated On: Jul 14, 2026
- Ocular
- Transdermal
- Mucosal
- Nasal
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The Correct Option is B
Approach Solution - 1
Nitrodisc is a type of transdermal drug delivery system (TDDS) designed to deliver nitroglycerin through the skin for the management of angina pectoris (chest pain due to reduced blood flow to the heart).
Transdermal systems like Nitrodisc use a patch that is applied to the skin, from which the drug diffuses across the skin layers and enters systemic circulation. This approach offers several advantages:
- Bypasses first-pass hepatic metabolism
- Provides controlled and sustained drug release
- Improves patient compliance due to ease of use
Nitrodisc contains a reservoir of nitroglycerin and often utilizes a rate-controlling membrane to regulate drug release over a specific duration, usually 24 hours. Explanation of options: - (a) Ocular: Intended for eye delivery (e.g., eye drops or inserts).
- (b) Transdermal: Correct. Nitrodisc is applied to the skin for systemic action.
- (c) Mucosal: Refers to buccal, rectal, or vaginal drug delivery.
- (d) Nasal: Involves drug delivery via nasal sprays or drops.
- Provides controlled and sustained drug release
- Improves patient compliance due to ease of use
Nitrodisc contains a reservoir of nitroglycerin and often utilizes a rate-controlling membrane to regulate drug release over a specific duration, usually 24 hours. Explanation of options: - (a) Ocular: Intended for eye delivery (e.g., eye drops or inserts).
- (b) Transdermal: Correct. Nitrodisc is applied to the skin for systemic action.
- (c) Mucosal: Refers to buccal, rectal, or vaginal drug delivery.
- (d) Nasal: Involves drug delivery via nasal sprays or drops.
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Approach Solution -2
This question asks which category of drug delivery system Nitrodisc belongs to. Looking at how Nitrodisc is actually applied and where the drug ends up shows which route it fits.
- Ocular: An ocular delivery system is placed in or on the eye, such as an eye drop or an ocular insert. Nitrodisc is not placed anywhere near the eye, so this route does not apply.
- Transdermal: Nitrodisc is a patch applied to the skin that releases nitroglycerin steadily so it can diffuse across the skin layers and enter the bloodstream, used to manage angina. Delivering a drug into systemic circulation through the skin, bypassing the gut and first-pass liver metabolism, is exactly what defines a transdermal system.
- Mucosal: Mucosal delivery applies a drug to a moist lining such as the buccal, rectal, or vaginal mucosa, absorbing across that membrane. Nitrodisc is applied to intact skin, not to a mucosal surface, so this does not match.
- Nasal: Nasal delivery uses sprays or drops absorbed through the nasal mucosa. Nitrodisc has no connection to the nasal route, since it is a skin patch, not something administered into the nose.
Since Nitrodisc is a patch worn on the skin that delivers nitroglycerin into the bloodstream through the skin's surface, it belongs to the transdermal route of delivery.
So the correct answer is Transdermal.
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