Question

Nephrotoxicity is the major adverse effect of

• A. Penicillins
• B. Aminoglycosides
• C. Tetracyclines
• D. Sulfonamides

Hint:

Aminoglycosides = Toxicity to "Ears and Rear" (Ototoxicity and Nephrotoxicity).

Answer 1

The Correct Option is B

Step 1: Concept
Many antibiotics are associated with specific organ-related toxicities that limit their clinical use.

Step 2: Meaning
Nephrotoxicity refers to toxicity to the kidneys, leading to impaired renal function.

Step 3: Analysis
While many drugs can affect the kidneys, Aminoglycosides are notorious for causing both nephrotoxicity and ototoxicity (ear damage). They accumulate in the renal tubular cells, leading to damage.

Step 4: Conclusion
Nephrotoxicity is a major and characteristic dose-limiting adverse effect of Aminoglycoside antibiotics.

Final Answer: (B)