Question

Nasal sprays should be maintained at a pH of:

• A. 6.4
• B. 6.8
• C. 6.2
• D. 6.0

Hint:

Nasal pH (6.4) is slightly more acidic than neutral (7.0) to match the natural mucus.

Answer 1

The Correct Option is A

Step 1: Concept
Nasal preparations are designed to be administered into the nasal cavity and must be compatible with the nasal mucosa.

Step 2: Meaning
The nasal cilia are highly sensitive to pH variations; deviations can lead to irritation or decreased ciliary movement.

Step 3: Analysis
The normal pH of nasal secretions is slightly acidic. To ensure maximum comfort and therapeutic efficacy, nasal sprays are typically buffered to a pH of 6.4.

Step 4: Conclusion
Maintaining the pH at 6.4 ensures the preparation is isotonic and non-irritating to the nasal environment.

Final Answer: (A)